The Chicago Journal

The Ongoing Shortage of a Vital Kids’ Antibiotic: Amoxicillin Woes Continue

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In the midst of a new season of infections, a concerning issue persists – the scarcity of a commonly prescribed antibiotic for children. This article delves into the current predicament faced by parents and pediatricians across the United States as they grapple with the unrelenting shortage of amoxicillin, a staple in treating childhood ailments.

The Lingering Dilemma: Shortage of Liquid Amoxicillin

As winter approaches, parents find themselves in a familiar predicament. The liquid formulations of amoxicillin, essential for treating strep throat, chest and sinus infections, and earaches in young children, remain in short supply. The U.S. Food and Drug Administration’s (FDA) drug shortage database confirms this shortage, leaving concerned caregivers seeking answers.

A Growing Concern: Implications for Respiratory Illness Season

David Margraf, a pharmaceutical research scientist at the University of Minnesota’s Resilient Drug Supply Project, highlights the impending crisis of respiratory illnesses in the context of the amoxicillin shortage. With no immediate resolution in sight, the shortage poses a significant challenge.

Capsules and Tablets Unaffected, but a Problem Persists

While amoxicillin capsules and tablets are still available, these forms aren’t suitable for young children who struggle to swallow pills. Hence, the reliance on liquid amoxicillin continues, intensifying the repercussions of the shortage.

Manufacturers’ Silence and Allocation

The scarcity is exacerbated by a lack of transparency from amoxicillin powder manufacturers, who provide the raw material for liquid formulations. Although most are still producing the antibiotic, they allocate it in limited quantities. Allocation serves as a double-edged sword, preventing monopolization of supply but leading to rapid depletion in pharmacies.

Impact on Prescriptions and Patient Health

Dr. Rohan Khazanchi and Dr. Ryan Brewster’s study reveals the clinical consequences of last winter’s amoxicillin shortage. Prescription rates plummeted by over 90%, as doctors turned to stronger alternatives, potentially causing harsher side effects and antibiotic resistance. This shift can also trigger shortages in substitute antibiotics.

Bigger Concerns Beyond Amoxicillin

Dr. Khazanchi emphasizes the broader issue of drug shortages affecting essential medications. The issue lies not only in amoxicillin but in the overall availability of generic and essential drugs.

Diverse Causes of Shortages

Manufacturers like Teva Pharmaceuticals attribute the shortage to increased demand, while Sandoz points to low prices driving manufacturers out of the market. The complex dynamics of pricing and demand contribute to the problem.

Opaque Manufacturer Practices

Some manufacturers remain tight-lipped about the reasons for the supply squeeze, making it challenging to address the root causes of the issue. This lack of transparency hampers efforts to secure adequate oral liquid supplies.

Amoxicillin’s Vulnerability and Cost

Amoxicillin is not alone in its vulnerability to shortages. A 2022 report from US Pharmacopeia highlights that antibiotics like amoxicillin are 42% more likely to face shortages. The low profitability of such drugs prompts manufacturers to allocate resources elsewhere.

FDA’s Limited Authority and Efforts

The FDA, while monitoring and reporting shortages, has limited authority to rectify them. The agency sympathizes with those affected and collaborates with stakeholders to mitigate the impact of intermittent or increased demand.

The Need for a Comprehensive Solution

Experts like Laura Bray advocate for a dedicated government entity to oversee drug supplies, ensuring the availability of essential medicines when needed. A model akin to the agricultural sector’s monitoring of grain and corn usage could prove invaluable in the pharmaceutical realm.

Coordination and Visibility

The absence of a single organization responsible for monitoring the entire drug supply chain results in coordination challenges. Establishing such oversight could enhance visibility and coordination.

Financial Incentives and Subsidies

One proposed solution involves offering pharmaceutical companies subsidies or financial incentives to produce necessary, cost-effective medications. A parallel with subsidies provided to farmers for food production illustrates the potential benefits of this approach.


The shortage of liquid amoxicillin underscores the broader challenges within the pharmaceutical industry. Transparency, government oversight, and innovative solutions are necessary to ensure the availability of essential medications for all. As we confront this pressing issue, the lessons learned may pave the way for a more resilient healthcare system.